Proteomic analysis of transdedifferentiated Schwann cells during Wallerian degeneration
نویسندگان
چکیده
منابع مشابه
Secretion of ATP from Schwann cells through lysosomal exocytosis during Wallerian degeneration.
The present study demonstrates that adenosine triphosphate (ATP) is released from Schwann cells through lysosomal exocytosis during Wallerian degeneration and in response to stimulation. In primary Schwann cell cultures, ATP was stored in lysosomal vesicles. ATP could then induce Ca(2+)-dependent lysosomal exocytosis. Among three stimulants of lysosomal exocytosis (glutamate, NH(4)Cl and zymosa...
متن کاملDouble-stranded RNA Induces Inflammatory Gene Expression in Schwann Cells: Implication in the Wallerian Degeneration
The incidence of facial nerve damage is often inevitable during surgery on the craniomaxillofacial area. Unlike in the central nervous system (CNS), neurons in the peripheral nervous system (PNS) have an intrinsic potential to regenerate upon axotomy. It is well known that a specific and orchestrated sequence of histopathological events is as a consequence of peripheral nerve injury, which even...
متن کاملStudies of Schwann cell proliferation. I. An analysis in tissue culture of proliferation during development, Wallerian degeneration, and direct injury
In this paper the stimuli for and pattern of Schwann cell proliferation are defined under various experimental conditions. We used a tissue culture system in which fetal rat dorsal root ganglia, treated to eliminate contaminating fibroblasts (Wood, P., 1976, Brain Res. 115:361--375), appear to recapitulate many aspects of the developing peripheral nervous system. We observed that: (a) prolifera...
متن کاملMotor axon excitability during Wallerian degeneration.
Axonal loss and degeneration are major factors in determining long-term outcome in patients with peripheral nerve disorders or injury. Following loss of axonal continuity, the isolated nerve stump distal to the lesion undergoes Wallerian degeneration in several phases. In the initial 'latent' phase, action potential propagation and structural integrity of the distal segment are maintained. The ...
متن کاملTransient lysosomal activation is essential for p75 nerve growth factor receptor expression in myelinated Schwann cells during Wallerian degeneration
Myelinated Schwann cells in the peripheral nervous system express the p75 nerve growth factor receptor (p75NGFR) as a consequence of Schwann cell dedifferentiation during Wallerian degeneration. p75NGFR has been implicated in the remyelination of regenerating nerves. Although many studies have shown various mechanisms underlying Schwann cell dedifferentiation, the molecular mechanism contributi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: IBRO Reports
سال: 2019
ISSN: 2451-8301
DOI: 10.1016/j.ibror.2019.07.803